NU-8165 is an inhibitor of the MDM2-p53 protein-protein interaction with anti-tumor activity. Optimization of NU-8165 was guided by MDM2 NMR titrations, which indicated key binding interaction regions. NU-8165 activated MDM2 and p21 transcription in cell-based assays and showed modest selectivity for wild-type p53 cell lines[1].
Molecular Weight:
407.89
CAS Number:
[849723-20-2]
Formula:
C24H22ClNO3
Target:
MDM-2/p53
Application Notes:
MCE Product type: Reference compound
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