AAT-008 is a potent, selective, and orally active prostaglandin EP4 receptor antagonist with Kis of 0.97 and 6.1 nM for recombinant human EP4 and recombinant rat EP4, respectively. AAT-008 exerts tumor growth delay in mice bearing CT26WT colon tumors when combined with radiotherapy. AAT-008 can be used for the study of acute and chronic inflammatory pain and cancer [1][2].
Molecular Weight:
414.81
Purity:
98.55
CAS Number:
[847727-81-5]
Formula:
C21H16ClFN2O4
Target:
Prostaglandin Receptor
Application Notes:
MCE Product type: Reference compound
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