PVZB1194 is a biphenyl-type inhibitor of Kinesin-5 ATPase activity that binds to the alpha4/alpha6 site of the motor domain in a nucleotide competitive manner. PVZB1194 has an IC50 of 0.12 µM for KSP ATPase. PVZB1194 induces mitotic arrest with the formation of a monopolar spindle, and inhibits HeLa cells proliferatio (IC50: 5.5 µM). PVZB1194 can be used in the study of tumors[1][2].
Molecular Weight:
319.27
Purity:
99.64
CAS Number:
[1141768-04-8]
Formula:
C13H9F4NO2S
Target:
Kinesin
Application Notes:
MCE Product type: Reference compound
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