Advantame is an N-substituted derivative of aspartame. Advantame is a high-intensity, low calorie sweetener. Advantame can interact with plasma protein. Advantame has the potential to produce hypotension and inhibit hERG K+ channel to produce carditoxicity. Advantame binds to T1R2/T1R3 taste GPCR to form an oligomeric functional selectivity of biased heteromers with NMBR to induce a significant sialidase activity in vitro. Advantame has maternal toxicity (gastrointestinal disturbances) in the prenatal developmental toxicity study in rabbits[1][2][3].
Molecular Weight:
476.52
Purity:
99.66
CAS Number:
[714229-20-6]
Formula:
C24H32N2O8
Target:
Taste Receptor
Application Notes:
MCE Product type: Reference compound
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