6,8-Diprenylnaringenin (Lonchocarpol A, Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and 3H-Methotrexate transport (IC50=0.41 µM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin[1][2].
Molecular Weight:
408.49
CAS Number:
[68236-11-3]
Formula:
C25H28O5
Target:
BCRP
Application Notes:
MCE Product type: Natural Products
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