BMS-984923, a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (Ki = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Abetao signaling without affecting physiological glutamate signaling[1][2].
Molecular Weight:
374.82
Purity:
99.50
CAS Number:
[1375752-78-5]
Formula:
C22H15ClN2O2
Target:
mGluR
Application Notes:
MCE Product type: Reference compound
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