SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer. It induces NF-kappaB signaling in cells expressing human TLR2 (EC50=0.55 µM) but not cells expressing human TLR3, -4, -5, -7, or -8 when used at concentrations ranging from 0.1 to 100 µM. SMU127 induces the production of TNF-alpha in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 0.01 to 1 µM. In vivo, SMU127 (0.1 mg/animal) reduces tumor volume in a 4T1 murine mammary carcinoma model.
Molecular Weight:
337.44
CAS Number:
[903864-87-9]
Formula:
C16H23N3O3S
Target:
TNF Receptor,Toll-like Receptor (TLR)
Application Notes:
MCE Product type: Reference compound1
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