P53R3 is a potent p53 reactivator and restores sequence-specific DNA binding of p53 hot spot mutants, including p53R175H, p53R248W and p53R273H. P53R3 induces p53-dependent antiproliferative effects with much higher specificity than PRIMA-1. P53R3 enhances the recruitment of wild-type p53 and p53M237I to several target gene promoters. P53R3 strongly enhances the mRNA, total protein and cell surface expression of the death receptor death receptor 5 (DR5). P53R3 is used for cancer research[1].
Molecular Weight:
592.56
Purity:
99.93
CAS Number:
[922150-12-7]
Formula:
C32H35Cl2N5O2
Target:
MDM-2/p53
Application Notes:
MCE Product type: Reference compound1
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