Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells[1][2].
Molecular Weight:
450.52
Purity:
98.05
CAS Number:
[65893-94-9]
Formula:
C27H30O6
Target:
Gli
Application Notes:
MCE Product type: Reference compound
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