EZH2-IN-1 (compound 3) is a selective and SAM-competitive EZH2 and EZH1 inhibitor with an IC50s of 32 nM, 197 nM and 213 nM for EZH2wt, EZH2 Y641N mutant and EZH1, respectively. EZH2-IN-1 reduces bulk H3K27me3 and H3K27me2 levels. EZH2-IN-1 has the potential for diffuse large B cell lymphoma research[1].
Molecular Weight:
490.00
CAS Number:
[1377997-28-8]
Formula:
C27H28ClN5O2
Target:
Histone Methyltransferase
Application Notes:
MCE Product type: Reference compound
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