PF-06273340 is a peripherally restricted pan-Trk inhibitor with IC50 values of 6, 4, 3 nM for TrkA, TrkB, and TrkC receptors. PF-06273340 binds in a DFG-out conformation, targeting less conserved kinase ligand binding domain regions outside the ATP binding pocket. PF-06273340 exhibits anti-hyperalgesic and analgesic effects. PF-06273340 can be used for the research of pain[1][2].
Molecular Weight:
479.92
Purity:
98.8
CAS Number:
[1402438-74-7]
Formula:
C23H22ClN7O3
Target:
Trk Receptor
Application Notes:
MCE Product type: Reference compound
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