ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 µM. ZINC05007751 shows antiproliferative activity against a panel of human cancer cell lines, and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity was observed against NEK2, NEK7, and NEK9[1].
Molecular Weight:
304.30
Purity:
99.33
CAS Number:
[591239-68-8]
Formula:
C18H12N2O3
Target:
NEKs
Application Notes:
MCE Product type: Reference compound1
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