NITD-916, a 4-hydroxy-2-pyridone derivative, is an orally active mycobacterial enoyl reductase InhA inhibitor with an IC50 of 570 nM. NITD-916 forms a ternary complex with InhA and NADH to block access to the fatty acyl substrate binding pocket. NITD-916 inhibition of InhA reduces the synthesis of mycolic acids and results in cell death. NITD-916 has potent anti-tuberculosis effects[1][2].
Molecular Weight:
311.42
Purity:
99.83
CAS Number:
[1614262-83-7]
Formula:
C20H25NO2
Target:
Bacterial
Application Notes:
MCE Product type: Reference compound1
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