MitoBloCK-1 is an inhibitor that blocks the import of substrates that use the TIM22 import pathway. MitoBloCK-1 inhibits import by preventing binding of substrate to tim9/10 complex to the substrate, thus the substrate failed to be reach the TIM22 translocon. MitoBloCK-1 inhibits protein import of TIM22 substrates into mitochondria. MitoBloCK-1 attenuates the import of the carrier proteins including the ADP/ATP and phosphate carriers. MitoBloCK-1 also inhibits the import of an additional carrier protein, PiC, and the outer membrane protein Tom40[1][2].
Molecular Weight:
368.25
Purity:
98.87
CAS Number:
[373370-73-1]
Formula:
C14H14BrN3O2S
Target:
Mitochondrial Metabolism
Application Notes:
MCE Product type: Reference compound
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