Surfen dihydrochloride is a potent heparan sulfate antagonist. Surfen inhibits FGF2 binding and signal transduction. Surfen binds to glycosaminoglycans and reduces tau hyperphosphorylation. Surfen dihydrochloride inhibits the activity of recombinant uronyl 2-O-sulfotransferase with an IC50 of approximately 2 µM. Surfen dihydrochloride inhibits HSV-1 viral infection. Surfen dihydrochloride inhibits neural differentiation, delays remyelination, and alleviates EAE[1][2][3][4][5][6].
Molecular Weight:
445.34
Purity:
99.93
CAS Number:
[5424-37-3]
Formula:
C21H22Cl2N6O
Target:
FGFR,HSV,Tau Protein
Application Notes:
MCE Product type: Reference compound1
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