Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific 14-3-3 protein-protein interactions. Fusicoccin sabilizes H+-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERalpha, GPIbalpha, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity[1][2][3][4].
Molecular Weight:
680.82
Purity:
96.30
CAS Number:
[20108-30-9]
Formula:
C36H56O12
Target:
Apoptosis
Application Notes:
MCE Product type: Natural Products
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