NVP-QAV680 is a potent and selective CRTh2 receptor antagonist with low nanomolar (nM) functional potency to inhibit CRTh2-driven activation of human eosinophils and Th2 lymphocytes. NVP-QAV680 exhibits good oral bioavailability and demonstrates efficacy in CRTh2-dependent mechanisms and allergic disease models in rats[1][2].
Molecular Weight:
358.41
CAS Number:
[872365-16-7]
Formula:
C18H18N2O4S
Target:
CRTH2 (GPR44),Prostaglandin Receptor
Application Notes:
MCE Product type: Reference compound
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