HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. HOIPIN-8 is a HOIPIN-1 derivative with enhanced the potency by 255-fold in the petit-LUBAC inhibition, and 10-fold and 4-fold in the LUBAC- and TNF-alpha-mediated NF-kappaB activation, respectively than HOIPIN-1. HOIPIN-1 is a promising tool to explore the cellular functions of LUBAC[1].
Molecular Weight:
456.38
Purity:
99.89
CAS Number:
[2519537-70-1]
Formula:
C23H15F2N4NaO3
Target:
E1/E2/E3 Enzyme
Application Notes:
MCE Product type: Reference compound1
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