IOX1, a chemical probe, is a potent broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 inhibits KDM4C, KDM4E, KDM2A, KDM3A and KDM6B with IC50 values of 0.6 µM, 2.3 µM, 1.8 µM, 0.1 µM and 1.4 µM, respectively[1][2]. IOX1 also inhibits ALKBH5[3].
Molecular Weight:
189.17
Purity:
99.89
CAS Number:
[5852-78-8]
Formula:
C10H7NO3
Target:
Histone Demethylase
Application Notes:
MCE Product type: Reference compound1
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