PNU-292137 is an orally active, potent CDK2 inhibitor with IC50s of 37 nM and 92 nM for CDK2/cyclin A and CDK2/cyclin E, respectively. PNU-292137 makes interactions with the hydrophobic pocket at the back of the CDK2 ATP pocket. PNU-292137 efficiently inhibits tumor cell proliferation in human colon and prostate tumor cell lines. PNU-292137 exhibits antitumor activity (TGI>50%) in a mouse xenograft model[1].
Molecular Weight:
291.35
Purity:
99.95
CAS Number:
[326823-27-2]
Formula:
C18H17N3O
Target:
CDK
Application Notes:
MCE Product type: Reference compound1
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