CI-966 is a potent, selective, orally active and brain-penetrant inhibitor of the GABA transporter GAT-1, with IC50s of 0.26 µM and 1.2 µM for hGAT-1, rGAT-1, respectively. CI-966 shows more than 200-fold selectivity over GAT-2, GAT-3, and BGT-3. CI-966 exhibits anticonvulsant and neuroprotective activities[1][2][3].
Molecular Weight:
473.41
CAS Number:
[110283-79-9]
Formula:
C23H21F6NO3
Target:
GABA Receptor
Application Notes:
MCE Product type: Reference compound1
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