OM137 is an aurora kinase inhibitor, with an IC50 of 21.7 µM (Aurora A kinase) and 2.4 µM (Aurora B kinase). OM137 also inhibits Cdk1/cyclinB and Cdk5/p25 with an approximate IC50 of 20 µM. OM137 reduces spindle checkpoint-signaling proteins (Mad2 and BubR1) at the kinetochores of chromosomes[1].
Molecular Weight:
306.34
CAS Number:
[292170-13-9]
Formula:
C13H14N4O3S
Target:
Aurora Kinase,CDK
Application Notes:
MCE Product type: Reference compound
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