MGS0039 is a type II group mGluR antagonist. MGS0039 has a high affinity for mGluR2 and mGluR3, with Ki values of 2.2 nM and 4.5 nM, respectively. MGS0039 can attenuate the inhibitory effect of glutamate-induced cyclic AMP formation triggered by Forskolin (HY-15371) in CHO cells expressing mGluR2/mGluR3. MGS0039 shows antidepressant-like activity in rats[1].
Molecular Weight:
378.18
CAS Number:
[569686-87-9]
Formula:
C15H14Cl2FNO5
Target:
mGluR
Application Notes:
MCE Product type: Reference compound
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