JY-XHe-053 is a potent and selective agonist of GABAA receptors containing the alpha5 subunit (Kis of 22.0 nM, 12.3 nM, 34.9 nM, 0.7 nM for alpha1, alpha2, alpha3, alpha5, respectively). JY-XHe-053 lacks significant anti-anxiety activity, despite its efficacy at alpha2- and alpha3-GABAA receptors[1][2].
Molecular Weight:
373.38
CAS Number:
[612526-36-0]
Formula:
C22H16FN3O2
Target:
GABA Receptor
Application Notes:
MCE Product type: Reference compound
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