UNC2025 is a potent, ATP-competitive, highly orally active and BBB-permeable Mer/Flt3 inhibitor with IC50 values of 0.74 nM and 0.8 nM, respectively. UNC2025 is >45-fold selectivity for MERTK relative to Axl (IC50= 122 nM, Ki = 13.3 nM). UNC2025 exhibits an excellent PK properties, and can be used for the investigation of acute leukemia[1][2][3].
Molecular Weight:
476.66
Purity:
99.92
CAS Number:
[1429881-91-3]
Formula:
C28H40N6O
Target:
FLT3
Application Notes:
MCE Product type: Reference compound
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