HS-438 is a potent and selective BCR-ABL inhibitor. HS-438 shows antiproliferative activity. HS-438 decreases the expression of phosphorylation of BCR-ABL (Tyr177). HS-438 induces apoptosis and cell cycle arrest at G0/G1 phase. HS-438 shows antitumor activity. HS-438 has the potential for the research of chronic myeloid leukemia (CML)[1].
Molecular Weight:
343.40
CAS Number:
[1430720-10-7]
Formula:
C17H17N3O3S
Target:
Apoptosis,Bcr-Abl
Application Notes:
Reference compound
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