JNJ10191584 (VUF6002) is an orally active and selective histamine H4 receptor antagonist with a Ki value of 26 nM. JNJ10191584 shows 540-fold selectivity to H4 receptor over H3 receptor with a Ki value of 14.1 µM. JNJ10191584 inhibits chemotaxis of eosinophils and mast cells with IC50 values of 530 nM and 138 nM, respectively[1][2].
Molecular Weight:
278.74
Purity:
99.90
CAS Number:
[73903-17-0]
Formula:
C13H15ClN4O
Target:
Histamine Receptor
Application Notes:
MCE Product type: Reference compound
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