Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase (P-p68) and a potent first-in-class anti-cancer agent. Supinoxin interacts with Y593 phosphorylated-p68 and attenuates the nuclear shuttling of beta-catenin. Supinoxin induces cell apoptosis and inhibits growth of TNBC cancer cell lines with IC50s ranging from 10 nM to 20 nM[1][2].
Molecular Weight:
441.46
Purity:
99.67
CAS Number:
[888478-45-3]
Formula:
C22H24FN5O4
Target:
Apoptosis,DNA/RNA Synthesis
Application Notes:
Reference compound
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