GGTI-2133, a peptidomimetic, is a selective geranylgeranyltransferase I (GGTase-I) inhibitor with an IC50 of 38 nM. GGTI-2133 shows 140-fold selectivity over farnesyltransferase (FTase) (IC50 of 5.4 µM). GGTI-2133 inhibits the geranylation of Rap-1A with an IC50 of 10 µM. GGTI-2133 can be used for the study of eosinophilic airway inflammation such as asthma[1][2].
Molecular Weight:
456.54
Purity:
98.50
CAS Number:
[191102-79-1]
Formula:
C27H28N4O3
Target:
GGTase
Application Notes:
MCE Product type: Reference compound1
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