NSC745887 (compound 25) is an inhibitor that targets DNA topoisomerase cleavage, activates the caspase-8/9-caspase-3-poly (ADP-ribose) polymerase cascade, and induces apoptosis in cancer cells. NSC745887 enhances gammaH2AX expression and causes DNA fragmentation leading to DNA damage[1][2].
Molecular Weight:
260.25
CAS Number:
[54490-26-5]
Formula:
C16H8N2O2
Target:
Apoptosis,Caspase
Application Notes:
MCE Product type: Reference compound
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