GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 µM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders[1].
Molecular Weight:
345.48
Purity:
99.11
CAS Number:
[1241902-40-8]
Formula:
C21H31NO3
Target:
Sodium Channel
Application Notes:
MCE Product type: Reference compound
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