FEN1-IN-1 (compound 1) is a small molecule flap endonuclease 1 (FEN1) inhibitor with antitumor activity. FEN1-IN-1 binds to the active site of FEN1 and partly achieves inhibition by the co-ordination of Mg2+ ions. FEN1-IN-1 initiaties a DNA damage response and activates the ATM checkpoint signalling pathway, the phosphorylation of histone H2AX and the ubiquitination of FANCD2 in mammalian cells. FEN1-IN-1 is promising for research of cancers[1].
Molecular Weight:
332.33
Purity:
99.85
CAS Number:
[824983-91-7]
Formula:
C15H12N2O5S
Target:
ATM/ATR,FLAP
Application Notes:
MCE Product type: Reference compound
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