dBET57 is an effective and selective BRD4BD1 degrader based on PROTAC technology, with the ability to induce cell apoptosis and anti-tumor activity. dBET57 mediates the recruitment of the E3 ubiquitin ligase CRL4Cereblon, showing a DC50/5h value of 500 nM for BRD4BD1[1][2].
Molecular Weight:
699.18
Purity:
99.94
CAS Number:
[1883863-52-2]
Formula:
C34H31ClN8O5S
Target:
Apoptosis,Epigenetic Reader Domain,PROTACs
Application Notes:
MCE Product type: Reference compound
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