MSC2504877 (M2912) is a potent and orally active tankyrase inhibitor with IC50s of 0.0007, 0.0008, 0.54 µM for TNKS, TNKS2, PARP1, respectively. MSC2504877 increases the expression of AXIN2 and TNKS protein levels and decreases beta-catenin levels. MSC2504877 shows anti-tumor activity[1].
Molecular Weight:
282.34
Purity:
99.25
CAS Number:
[1460286-21-8]
Formula:
C17H18N2O2
Target:
PARP
Application Notes:
MCE Product type: Reference compound
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