SC-68448 (S 448) is a selective alphavbeta3 antagonist (IC50 = 1 nM). SC-68448 inhibits alphavbeta3-mediated endothelial cell proliferation. SC-68448 reduces the total level of alphavbeta6 in NHBE cells. SC-68448 inhibits angiogenesis in a rat corneal neoplasia model. SC-68448 inhibits tumor growth and completely prevents the development of hypercalcemia in a rat Ledich cell tumor model. SC-68448 can be used in research on cardiovascular and cerebrovascular diseases such as hypercalcemia and cancers such as testicular interstitial cell tumors[1][2].
Molecular Weight:
452.29
CAS Number:
[188804-07-1]
Formula:
C19H19Cl2N5O4
Target:
Integrin
Application Notes:
MCE Product type: Reference compound1
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