Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a von Hippel-Lindau ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively[1].
Molecular Weight:
934.51
Purity:
99.98
CAS Number:
[2230821-27-7]
Formula:
C47H57ClFN7O8S
Target:
EGFR,PROTACs
Application Notes:
Reference compound
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