SB772077B is a ROCK inhibitor. SB772077B has an anti-inflammatory activity and enhances aqueous outflow facility (OF) by inactivating RhoA/ROCK signal pathway. SB772077B significantly reduces the mRNA level of beta-catenin and protein level of fibrotic markers, such as vinculin, fibronectin, collagen 1 A and vimentin. SB772077B also has vasodialatory activity and decreases pulmonary and systemic blood pressure. SB772077B can be used for glaucoma research and pulmonary hypertensive disorder research[1][2].
Molecular Weight:
342.36
CAS Number:
[785774-34-7]
Formula:
C15H18N8O2
Target:
Collagen,ROCK,beta-catenin
Application Notes:
MCE Product type: Reference compound
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