CTPI-2 is a third-generation mitochondrial citrate carrier SLC25A1 inhibitor with a KD of 3.5 µM. CTPI-2 inhibits glycolysis, PPARgamma, and its downstream target the glucose transporter GLUT4. CTPI-2 halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, and starkly mitigating obesity induced by a high-fat diet. Antitumor activity[1][2].
Molecular Weight:
356.74
Purity:
99.99
CAS Number:
[68003-38-3]
Formula:
C13H9ClN2O6S
Target:
Mitochondrial Metabolism
Application Notes:
MCE Product type: Reference compound
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