PCNA-I1 is a selective small molecule inhibitor targeting proliferating cell nuclear antigen (PCNA) with anticancer activity. PCNA-I1 can stabilize the PCNA trimer structure (Kd=0.14-0.41µM), reduce its binding to chromatin, induce tumor cell cycle arrest, inhibit DNA replication and repair, and enhance the anti-tumor effect of DNA damaging agents. PCNA-I1 can be used in the study of targeted therapy for prostate cancer, lung cancer and other tumors[1][2][3].
Molecular Weight:
310.37
Purity:
98.78
CAS Number:
[444930-42-1]
Formula:
C17H14N2O2S
Target:
Apoptosis,DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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