AZ10397767 is an orally active, selective CXCR2 receptor antagonist with an IC50 of 1 nM. AZ10397767 attenuates the Oxaliplatin (HY-17371)-induced NF-kappaB transcriptional activity and potentiates Oxaliplatin-induced apoptosis in androgen-independent prostate cancer (AIPC) cells. AZ10397767 significantly inhibits neutrophil recruitment into tumors which then adversely affects tumor growth in vitro and in vivo[1][2][3][4].
Molecular Weight:
400.88
CAS Number:
[333742-63-5]
Formula:
C15H14ClFN4O2S2
Target:
CXCR
Application Notes:
MCE Product type: Reference compound
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