RO5126946 is a selective, orally active alpha7 nAChR allosteric potentiator with EC50 values of 0.06 µM (halpha7 nAChR) and 770 nM (alpha7 nAChR), and it crosses the blood-brain barrier. RO5126946 enhances synaptic transmission and positively modulates GABA-ergic responses by increasing peak current, slowing current decay, and elevating the frequency of spontaneous inhibitory postsynaptic currents, without affecting the recovery of receptors from the desensitized state. RO5126946 not only enhances subthreshold nicotine effects and improves associative learning, but also does not interfere with the original pro-cognitive effects of nicotine. RO5126946 can be used to study cognitive impairments associated with diseases such as Alzheimers disease and schizophrenia[1].
Molecular Weight:
408.90
CAS Number:
[1137233-79-4]
Formula:
C19H21ClN2O4S
Target:
nAChR
Application Notes:
MCE Product type: Reference compound
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