EC-70124 is an orally active multikinase inhibitor targeting IKKbeta and JAK2. EC-70124 blocks IkB phosphorylation and STAT3 (Tyr705) activation, suppressing NF-kappaB nuclear translocation and STAT3 transcriptional activity. EC-70124 reduces tumor growth and cancer stem cell (CSC) populations in prostate cancer cells and xenograft models. EC-70124 is promising for research of prostate cancer[1].
Molecular Weight:
453.45
CAS Number:
[1185908-92-2]
Formula:
C26H19N3O5
Target:
IKK,JAK,NF-kappaB,STAT
Application Notes:
MCE Product type: Reference compound
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