M-525 is a first-in-class, highly potent, irreversible and covalent menin-MLL protein-protein interaction inhibitor. M-525 binds to menin with an IC50 of 3 nM and achieves low nanomolar potencies in cell growth inhibition and in suppression of MLL regulated gene expression in MLL leukemia cells. Anti-leukemia activity[1].
Molecular Weight:
734.92
CAS Number:
[2173582-08-4]
Formula:
C39H51FN6O5S
Target:
Epigenetic Reader Domain
Application Notes:
MCE Product type: Reference compound
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