HNMPA-(AM)3 is a cell-permeable and selective insulin receptor tyrosine kinase inhibitor analog of HNMPA. HNMPA-(AM)3 greatly inhibits the ability of prothoracicotropic hormone (PTTH) to activate ERK phosphorylation and stimulate ecdysteroidogenesis. HNMPA-(AM)3 is also effective in inhibiting ecdysteroid production (IC50=14.2 µM) and insulin receptor activity (IC50 is 14.2 µM and 200 µM in mosquitoes and mammals, respectively)[1][2].
Molecular Weight:
454.36
Purity:
98.04
CAS Number:
[120944-03-8]
Formula:
C20H23O10P
Target:
Insulin Receptor
Application Notes:
MCE Product type: Reference compound
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