NSC 1008 is a selective Ras converting enzyme 1 (Rce1) inhibitor that reduces Rce1 in vitro activity with a human IC50 of 8.9 µM. NSC 1008 demonstrates selectivity for Rce1 by not inhibiting human Ste24 or huamn FTase. NSC 1008 exhibits low cell toxicity, and induces mislocalization of EGFP-Ras from the plasma membrane in cancer cells. NSC 1008 can be used for the research of cancer[1].
Molecular Weight:
326.40
CAS Number:
[5335-95-5]
Formula:
C22H18N2O
Target:
Ras
Application Notes:
MCE Product type: Reference compound
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