AD-2646 (LCL102), a ceramide analog, can kill leukemic T cells (EC50: 40 µM). AD-2646 triggers the cleavage of caspase-8, -9 and -3, as well as the caspase substrate PARP. AD-2646 is a ceramidase inhibitor. AD-2646 induces an accumulation of endogenous ceramide owing to perturbed ceramide metabolism[1][2].
Molecular Weight:
408.57
CAS Number:
[366487-89-0]
Formula:
C23H40N2O4
Target:
Caspase,Ceramidase,PARP
Application Notes:
MCE Product type: Reference compound
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