GNE-431 is a potent, selective and noncovalent ''pan-BTK inhibitor against C481R, T474I and T474Ms mutants. GNE-431 shows potency against wild-type BTK (IC50= 3.2 nM) and potency against C481S mutant (IC50= 2.5 nM). GNE-431 is proming for rasearch of haematological disorders and autoimmune diseases[1][2].
Molecular Weight:
564.64
CAS Number:
[1433820-83-7]
Formula:
C30H32N10O2
Target:
Btk
Application Notes:
MCE Product type: Reference compound
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