TA-0201 is a novel orally active, competitive, non-peptide endothelin receptor antagonist. TA-0201 antagonizes the specific binding of [125I]ET-1 to cloned human receptors of ETA and ETB with Ki values of 15 pM and 41 nM, respectively. TA-0201 inhibits the pressor response to the exogenous big ET-1[1].
Molecular Weight:
614.51
CAS Number:
[169679-53-2]
Formula:
C27H28BrN5O5S
Target:
Endothelin Receptor
Application Notes:
MCE Product type: Reference compound
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