SMDC818909, CAS [[1147823-21-9]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-124253
Supplier Catalog Number:
HY-124253
Alternative Catalog Number:
MCE-HY-124253-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
SMDC818909 is an indole amide-derived uncompetitive inhibitor targeting p97 AAA+ ATPase, with an IC50 of 3.5 µM and a Ka of 9.1 µM. SMDC818909 binds to the D2 ATPase domain of p97, preferentially associates with the ADP-bound conformation of p97, allosterically blocks the ATP hydrolysis cycle of p97, and inhibits its mediated intracellular protein homeostasis regulatory function. SMDC818909 is applied to the research and development of p97-targeted antitumor drugs, as well as studies on cancer-related proteotoxic stress mechanisms[1][2][3].
Molecular Weight:
267.29
CAS Number:
[1147823-21-9]
Formula:
C14H13N5O
Application Notes:
MCE Product type: Reference compound
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