AA147 is a endoplasmic reticulum (ER) proteostasis regulator. AA147 promotes protection against oxidative damage in neuronal cells and prevents endothelial barrier dysfunction by activating ATF6 arm (selectively) of the unfolded protein response (UPR) and the NRF2 oxidative stress response. AA147 can rebalances XBP1s expression in vivo, and also induces survival motor neuron (SMN) expression and spinal motorneuron (MN) protection[1][2][3][4].
Molecular Weight:
255.31
Purity:
99.81
CAS Number:
[393121-74-9]
Formula:
C16H17NO2
Target:
ATF6,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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